High-resolution X-ray CT screening of mutant mouse models

M. J. Paulus, S. S. Gleason, H. Sari-Sarraf, D. K. Johnson, C. J. Foltz, D. W. Austin, M. E. Easterly, E. J. Michaud, M. S. Dhar, P. R. Hunsicker, J. W. Wall, M. Schell

Research output: Contribution to journalConference articlepeer-review

19 Scopus citations

Abstract

A dedicated small animal x-ray computed tomography system has been developed to screen mutagenized mice for anatomical phenotypes. The key components of the data acquisition instrumentation are described along with the system performance parameters. Image reconstruction, visualization and segmentation software algorithms are described. Two contrast media regimens are described and representative studies of mice with adipose, soft and skeletal tissue abnormalities are presented.

Original languageEnglish
Pages (from-to)270-279
Number of pages10
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume3921
StatePublished - 2000
EventOptical Diagnostics of Living Cells III - San Jose, CA, USA
Duration: Jan 24 2000Jan 25 2000

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