TY - GEN
T1 - High-homogeneity functional parcellation of human brain for investigating robust functional connectivity
AU - Liu, Xiangyu
AU - Xie, Hua
AU - Nutter, Brian
AU - Mitra, Sunanda
N1 - Publisher Copyright:
© 2018 IEEE.
PY - 2018/9/21
Y1 - 2018/9/21
N2 - Over the years, resting state functional magnetic resonance imaging (rsfMRI) has been a preferred design tool to analyze human brain functions and brain parcellations. Several different statistical methods have been proposed to study functional connectivity and generate various parcellation atlases based on corresponding connectivity maps. In this study, we employ a sliding window correlation method to generate accurate individual voxel-wise dynamic functional connectivity maps, based on which the brain can be parcellated into highly homogeneous functional parcels. Because there is no ground truth for functional brain parcellation, we accomplish parcellation via k-means clustering to compare with other available parcellations. With temporal characteristics of functional connectivity taken into consideration, high homogeneity can be observed in high resolution parcellation of human brain.
AB - Over the years, resting state functional magnetic resonance imaging (rsfMRI) has been a preferred design tool to analyze human brain functions and brain parcellations. Several different statistical methods have been proposed to study functional connectivity and generate various parcellation atlases based on corresponding connectivity maps. In this study, we employ a sliding window correlation method to generate accurate individual voxel-wise dynamic functional connectivity maps, based on which the brain can be parcellated into highly homogeneous functional parcels. Because there is no ground truth for functional brain parcellation, we accomplish parcellation via k-means clustering to compare with other available parcellations. With temporal characteristics of functional connectivity taken into consideration, high homogeneity can be observed in high resolution parcellation of human brain.
KW - Human brain
KW - functional connectivity
KW - homogeneity
KW - parcellation
KW - rsfMRI
UR - http://www.scopus.com/inward/record.url?scp=85055556352&partnerID=8YFLogxK
U2 - 10.1109/SSIAI.2018.8470321
DO - 10.1109/SSIAI.2018.8470321
M3 - Conference contribution
AN - SCOPUS:85055556352
T3 - Proceedings of the IEEE Southwest Symposium on Image Analysis and Interpretation
SP - 41
EP - 44
BT - 2018 IEEE Southwest Symposium on Image Analysis and Interpretation, SSIAI 2018 - Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2018 IEEE Southwest Symposium on Image Analysis and Interpretation, SSIAI 2018
Y2 - 8 April 2018 through 10 April 2018
ER -