Halogeno aldol reaction of ethyl vinyl ketone and aldehydes mediated by titanium tetrachloride

Han Xun Wei, Subramanian Karur, Guigen Li

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

A three-component halogeno aldol reaction has been developed by using titanium tetrachloride as the halogen source as well as the Lewis acid mediator. The dehydration and elimination of hydrogen chloride were inhibited by conducting the reaction at 0 °C in dichloromethane or at room temperature with a shortened reaction time. Seven examples were examined, giving good to high yields (61 - 92%) and modest stereoselectivity (syn/anti: 2.2/1.0 - 8.4/1.0).

Original languageEnglish
Pages (from-to)1408-1416
Number of pages9
JournalMolecules
Volume5
Issue number12
DOIs
StatePublished - Dec 2000

Keywords

  • Aldol reaction
  • Halides
  • Titanium tetrachloride

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