Halogeno aldol reaction of ethyl vinyl ketone and aldehydes mediated by titanium tetrachloride

Han Xun Wei; Subramanian Karur; Guigen Li

doi:10.3390/51201408

Halogeno aldol reaction of ethyl vinyl ketone and aldehydes mediated by titanium tetrachloride

Han Xun Wei, Subramanian Karur, Guigen Li

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A three-component halogeno aldol reaction has been developed by using titanium tetrachloride as the halogen source as well as the Lewis acid mediator. The dehydration and elimination of hydrogen chloride were inhibited by conducting the reaction at 0 °C in dichloromethane or at room temperature with a shortened reaction time. Seven examples were examined, giving good to high yields (61 - 92%) and modest stereoselectivity (syn/anti: 2.2/1.0 - 8.4/1.0).

Original language	English
Pages (from-to)	1408-1416
Number of pages	9
Journal	Molecules
Volume	5
Issue number	12
DOIs	https://doi.org/10.3390/51201408
State	Published - Dec 2000

Keywords

Aldol reaction
Halides
Titanium tetrachloride

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abstract = "A three-component halogeno aldol reaction has been developed by using titanium tetrachloride as the halogen source as well as the Lewis acid mediator. The dehydration and elimination of hydrogen chloride were inhibited by conducting the reaction at 0 °C in dichloromethane or at room temperature with a shortened reaction time. Seven examples were examined, giving good to high yields (61 - 92%) and modest stereoselectivity (syn/anti: 2.2/1.0 - 8.4/1.0).",

keywords = "Aldol reaction, Halides, Titanium tetrachloride",

author = "Wei, {Han Xun} and Subramanian Karur and Guigen Li",

year = "2000",

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AU - Wei, Han Xun

AU - Karur, Subramanian

AU - Li, Guigen

PY - 2000/12

Y1 - 2000/12

N2 - A three-component halogeno aldol reaction has been developed by using titanium tetrachloride as the halogen source as well as the Lewis acid mediator. The dehydration and elimination of hydrogen chloride were inhibited by conducting the reaction at 0 °C in dichloromethane or at room temperature with a shortened reaction time. Seven examples were examined, giving good to high yields (61 - 92%) and modest stereoselectivity (syn/anti: 2.2/1.0 - 8.4/1.0).

AB - A three-component halogeno aldol reaction has been developed by using titanium tetrachloride as the halogen source as well as the Lewis acid mediator. The dehydration and elimination of hydrogen chloride were inhibited by conducting the reaction at 0 °C in dichloromethane or at room temperature with a shortened reaction time. Seven examples were examined, giving good to high yields (61 - 92%) and modest stereoselectivity (syn/anti: 2.2/1.0 - 8.4/1.0).

KW - Aldol reaction

KW - Halides

KW - Titanium tetrachloride

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U2 - 10.3390/51201408

DO - 10.3390/51201408

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VL - 5

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JO - Molecules

JF - Molecules

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ER -

Halogeno aldol reaction of ethyl vinyl ketone and aldehydes mediated by titanium tetrachloride

Abstract

Keywords

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