Growth Factor and Catabolic Cytokine Concentrations are Influenced by the Cellular Composition of Platelet-Rich Plasma

Emily Sundman, Brian J. Cole, Lisa A. Fortier

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Previous studies of bioactive molecules in platelet-rich plasma (PRP) have documented growth factor concentrations that promote tissue healing. However, the effects of leukocytes and inflammatory molecules in PRP have not been defined.Hypothesis: The hypothesis for this study was that the concentration of growth factors and catabolic cytokines would be dependent on the cellular composition of PRP.Study Design: Controlled laboratory study.Methods: Platelet-rich plasma was made from 11 human volunteers using 2 commercial systems: Arthrex ACP (Autologous Conditioned Plasma) Double Syringe System (PRP-1), which concentrates platelets and minimizes leukocytes, and Biomet GPS III Mini Platelet Concentrate System (PRP-2), which concentrates both platelets and leukocytes. Transforming growth factor-β1 (TGF-β1), platelet-derived growth factor-AB (PDGF-AB), matrix metalloproteinase-9 (MMP-9), and interleukin-1β (IL-1β) were measured with enzyme-linked immunosorbent assay (ELISA).Res
Original languageEnglish
Pages (from-to)2135-2140
JournalAmerican Journal of Sports Medicine
StatePublished - Oct 1 2011

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