Growth Charts for Prader-Willi Syndrome during Growth Hormone Treatment

Merlin G. Butler; Jaehoon Lee; Devin M. Cox; Ann M. Manzardo; June Anne Gold; Jennifer L. Miller; Elizabeth Roof; Elisabeth Dykens; Virginia Kimonis; Daniel J. Driscoll

doi:10.1177/0009922815617973

Growth Charts for Prader-Willi Syndrome during Growth Hormone Treatment

Merlin G. Butler, Jaehoon Lee, Devin M. Cox, Ann M. Manzardo, June Anne Gold, Jennifer L. Miller, Elizabeth Roof, Elisabeth Dykens, Virginia Kimonis, Daniel J. Driscoll

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Abstract

The purpose of the current study was to develop syndrome-specific standardized growth curves for growth hormone-treated Prader-Willi syndrome (PWS) individuals aged 0 to 18 years. Anthropometric growth-related measures were obtained on 171 subjects with PWS who were treated with growth hormone for at least 40% of their lifespan. They had no history of scoliosis. PWS standardized growth curves were developed for 7 percentile ranges using the LMS method for weight, height, head circumference, weight/length, and BMI along with normative 3rd, 50th, and 97th percentiles plotted using control data from the literature and growth databases. Percentiles were plotted on growth charts for comparison purposes. Growth hormone treatment appears to normalize stature and markedly improves weight in PWS compared with standardized curves for non-growth hormone-treated PWS individuals. Growth chart implications and recommended usage are discussed.

Original language	English
Pages (from-to)	957-974
Number of pages	18
Journal	Clinical Pediatrics
Volume	55
Issue number	10
DOIs	https://doi.org/10.1177/0009922815617973
State	Published - Sep 1 2016

Keywords

Prader-Willi syndrome
children
genetic subtype
growth hormone treatment
infants
standardized growth curves

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title = "Growth Charts for Prader-Willi Syndrome during Growth Hormone Treatment",

abstract = "The purpose of the current study was to develop syndrome-specific standardized growth curves for growth hormone-treated Prader-Willi syndrome (PWS) individuals aged 0 to 18 years. Anthropometric growth-related measures were obtained on 171 subjects with PWS who were treated with growth hormone for at least 40% of their lifespan. They had no history of scoliosis. PWS standardized growth curves were developed for 7 percentile ranges using the LMS method for weight, height, head circumference, weight/length, and BMI along with normative 3rd, 50th, and 97th percentiles plotted using control data from the literature and growth databases. Percentiles were plotted on growth charts for comparison purposes. Growth hormone treatment appears to normalize stature and markedly improves weight in PWS compared with standardized curves for non-growth hormone-treated PWS individuals. Growth chart implications and recommended usage are discussed.",

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author = "Butler, {Merlin G.} and Jaehoon Lee and Cox, {Devin M.} and Manzardo, {Ann M.} and Gold, {June Anne} and Miller, {Jennifer L.} and Elizabeth Roof and Elisabeth Dykens and Virginia Kimonis and Driscoll, {Daniel J.}",

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AU - Lee, Jaehoon

AU - Cox, Devin M.

AU - Manzardo, Ann M.

AU - Gold, June Anne

AU - Miller, Jennifer L.

AU - Roof, Elizabeth

AU - Dykens, Elisabeth

AU - Kimonis, Virginia

AU - Driscoll, Daniel J.

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N2 - The purpose of the current study was to develop syndrome-specific standardized growth curves for growth hormone-treated Prader-Willi syndrome (PWS) individuals aged 0 to 18 years. Anthropometric growth-related measures were obtained on 171 subjects with PWS who were treated with growth hormone for at least 40% of their lifespan. They had no history of scoliosis. PWS standardized growth curves were developed for 7 percentile ranges using the LMS method for weight, height, head circumference, weight/length, and BMI along with normative 3rd, 50th, and 97th percentiles plotted using control data from the literature and growth databases. Percentiles were plotted on growth charts for comparison purposes. Growth hormone treatment appears to normalize stature and markedly improves weight in PWS compared with standardized curves for non-growth hormone-treated PWS individuals. Growth chart implications and recommended usage are discussed.

AB - The purpose of the current study was to develop syndrome-specific standardized growth curves for growth hormone-treated Prader-Willi syndrome (PWS) individuals aged 0 to 18 years. Anthropometric growth-related measures were obtained on 171 subjects with PWS who were treated with growth hormone for at least 40% of their lifespan. They had no history of scoliosis. PWS standardized growth curves were developed for 7 percentile ranges using the LMS method for weight, height, head circumference, weight/length, and BMI along with normative 3rd, 50th, and 97th percentiles plotted using control data from the literature and growth databases. Percentiles were plotted on growth charts for comparison purposes. Growth hormone treatment appears to normalize stature and markedly improves weight in PWS compared with standardized curves for non-growth hormone-treated PWS individuals. Growth chart implications and recommended usage are discussed.

KW - Prader-Willi syndrome

KW - children

KW - genetic subtype

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KW - infants

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ER -

Growth Charts for Prader-Willi Syndrome during Growth Hormone Treatment

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Keywords

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