Group-assisted purification (gap) for protection of amino acids using n-phosphonyl functional groups

Guanghui An; Cole Seifert; Hao Sun; Yi Pan; Guigen Li

doi:10.3987/COM-14-S(K)25

Group-assisted purification (gap) for protection of amino acids using n-phosphonyl functional groups

Guanghui An, Cole Seifert, Hao Sun, Yi Pan, Guigen Li

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Various phosphonyl halides have been synthesized and utilized as protection groups for amino acids. The protection synthesis was performed via GAP (Group-Assisted Purification) procedure under convenient conditions without the use of column chromatography and recrystallization. The synthesis can be carried out on applicational scales with excellent yields (82% - 98%). The phosphonyl protection of amino acids would provide a new greener tool for GAP peptide synthesis.

Original language	English
Pages (from-to)	344-356
Number of pages	13
Journal	Heterocycles
Volume	90
Issue number	1
DOIs	https://doi.org/10.3987/COM-14-S(K)25
State	Published - 2015

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abstract = "Various phosphonyl halides have been synthesized and utilized as protection groups for amino acids. The protection synthesis was performed via GAP (Group-Assisted Purification) procedure under convenient conditions without the use of column chromatography and recrystallization. The synthesis can be carried out on applicational scales with excellent yields (82% - 98%). The phosphonyl protection of amino acids would provide a new greener tool for GAP peptide synthesis.",

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AU - An, Guanghui

AU - Seifert, Cole

AU - Sun, Hao

AU - Pan, Yi

AU - Li, Guigen

PY - 2015

Y1 - 2015

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AB - Various phosphonyl halides have been synthesized and utilized as protection groups for amino acids. The protection synthesis was performed via GAP (Group-Assisted Purification) procedure under convenient conditions without the use of column chromatography and recrystallization. The synthesis can be carried out on applicational scales with excellent yields (82% - 98%). The phosphonyl protection of amino acids would provide a new greener tool for GAP peptide synthesis.

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DO - 10.3987/COM-14-S(K)25

M3 - Article

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SP - 344

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JO - Heterocycles

JF - Heterocycles

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