Abstract
Various phosphonyl halides have been synthesized and utilized as protection groups for amino acids. The protection synthesis was performed via GAP (Group-Assisted Purification) procedure under convenient conditions without the use of column chromatography and recrystallization. The synthesis can be carried out on applicational scales with excellent yields (82% - 98%). The phosphonyl protection of amino acids would provide a new greener tool for GAP peptide synthesis.
Original language | English |
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Pages (from-to) | 344-356 |
Number of pages | 13 |
Journal | Heterocycles |
Volume | 90 |
Issue number | 1 |
DOIs | |
State | Published - 2015 |