Group-assisted purification (gap) for protection of amino acids using n-phosphonyl functional groups

Guanghui An, Cole Seifert, Hao Sun, Yi Pan, Guigen Li

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Various phosphonyl halides have been synthesized and utilized as protection groups for amino acids. The protection synthesis was performed via GAP (Group-Assisted Purification) procedure under convenient conditions without the use of column chromatography and recrystallization. The synthesis can be carried out on applicational scales with excellent yields (82% - 98%). The phosphonyl protection of amino acids would provide a new greener tool for GAP peptide synthesis.

Original languageEnglish
Pages (from-to)344-356
Number of pages13
JournalHeterocycles
Volume90
Issue number1
DOIs
StatePublished - 2015

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