Glycerophospholipid profiles of bats with white nose syndrome

Evan L Pannkuk, Liam McGuire, Lisa Warnecke, James M Turner, Craig KR Willis, Thomas S Risch

Research output: Contribution to journalArticlepeer-review


Pseudogymnoascus destructans (Pd) is an ascomycetous fungus responsible for the disease dubbed white nose syndrome (WNS) and massive mortalities of cave dwelling bats. The fungus infects bat epidermal tissue causing damage to integumentary cells and pilosebaceous units. Differences in epidermal lipid composition caused by Pd infection could have drastic consequences for a variety of physiological functions, including innate immune efficiency and water retention. While bat surface lipid and stratum corneum lipid composition have been described; the differences in epidermal lipid content between healthy tissue and Pd infected tissue have not been documented. In this study, we analyzed the effect of wing damage from Pd infection on the epidermal polar lipid composition (glycerophospholipids [GPs] and sphingomyelin [SM]) of little brown bats (Myotis lucifugus). We hypothesized that bats infected with Pd would have altered lipid profiles compared to healthy bats. Polar lipids from th
Original languageEnglish
Pages (from-to)425-432
JournalPhysiological and Biochemical Zoology
StatePublished - May 7 2015


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