Glucose regulates pancreatic preprosomatostatin I expression

Gregory T. Melroe, Melissa M. Ehrman, Jeffrey D. Kittilson, Mark A. Sheridan

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Rainbow trout were used as a model system to evaluate the role of glucose in regulating the expression of preprosomatostatin I. Glucose increased pancreatic levels of preprosomatostatin I mRNA in vivo, in concert with elevated plasma somatostatin levels, and in vitro. Glucose-stimulated expression of preprosomatostatin I mRNA required the uptake, phosphorylation, and subsequent metabolism of the sugar in pancreatic islets. These results suggest that glucose modulates both the production and release of somatostatin. Copyright (C) 2000 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)115-118
Number of pages4
JournalFEBS Letters
Volume465
Issue number2-3
DOIs
StatePublished - Jan 14 2000

Keywords

  • Rainbow trout model system
  • Somatostatin
  • mRNA slot-blot quantitation technique

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