Genetic environment of blaCTXM-15 beta-lactamase gene in Enterobacteriaceae from Africa

Babafela Awosile, Michael Agbaje

Research output: Contribution to journalArticlepeer-review

Abstract

The most widely distributed blaCTX-M gene on a global scale is blaCTX-M-15. The dissemination has been associated with clonal spread and different types of mobile genetic elements. The objective of this review was to describe the genetic environments of the blaCTX-M-15 gene detected from Enterobacteriaceae in published literature from Africa. A literature search for relevant articles was performed through PubMed, AJOL, and Google Scholar electronic databases; 43 articles from 17 African countries were included in the review based on the eligibility criteria. Insertion sequences were reported as part of the genetic environment of blaCTX-M-15 gene in 32 studies, integrons in 13 studies, and plasmids in 23 studies. In this review, five insertion sequences including ISEcp1, IS26, orf447, IS903, and IS3 have been detected which are associated with the genetic environment of blaCTX-M-15 in Africa. Seven different genetic patter
Original languageEnglish
Pages (from-to)383-394
JournalMicrobiology Research
DOIs
StatePublished - Apr 19 2021

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