Generation of a chemical gradient across an array of 256 cell cultures in a single chip

Himali Somaweera, Akif Ibragimov, Dimitri Pappas

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A microfluidic diffusion diluter to create stable chemical gradients across an array of cell cultures was demonstrated. The device enabled concentration based studies to be conducted at 256 different concentrations across individual, low shear cell cultures. A gradient of staurosporine on cells stained with Mitotracker Deep Red (MTDR) showed a concentration-based effect on cell apoptosis across the cell culture array.

Original languageEnglish
Pages (from-to)5566-5571
Number of pages6
JournalAnalyst
Volume138
Issue number19
DOIs
StatePublished - Oct 7 2013

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