Generation of 3D nanofiber structure by divergence electrospinning for tissue engineering scaffold

Yingge Zhou, George Z. Tan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Fabrication of biomimetic cell microenvironment closely resembling the native tissues is critical for regenerative medicine. It remains challenging to create a 3D fibrous microstructure of extracellular matrix on a clinical-relevant scale. In this paper we presented a novel divergence electrospinning strategy for 3D nanofiber structure fabrication. The electrospinning induced by a double-bevel collector was able to quickly generate a multi-layer scaffold, comprised of uniaxially aligned nanofibers, at centimeter scales in all dimensions. The results showed that the internal nanofiber distribution was largely determined by the inclination angle of the axisymmetric bevels of the collector. A larger inclination angle alleviated the polarization of the fiber distribution due to a lower electric force gradient between the spinneret and the bevel surfaces. This technique can be applied in engineering of musculoskeletal soft tissues in which fibrous cytoskeletal organization is critical.

Original languageEnglish
Title of host publicationAdditive Manufacturing; Bio and Sustainable Manufacturing
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Print)9780791851357
DOIs
StatePublished - 2018
EventASME 2018 13th International Manufacturing Science and Engineering Conference, MSEC 2018 - College Station, United States
Duration: Jun 18 2018Jun 22 2018

Publication series

NameASME 2018 13th International Manufacturing Science and Engineering Conference, MSEC 2018
Volume1

Conference

ConferenceASME 2018 13th International Manufacturing Science and Engineering Conference, MSEC 2018
CountryUnited States
CityCollege Station
Period06/18/1806/22/18

Keywords

  • 3D electrospinning
  • Nanofiber
  • Scaffold fabrication
  • Tissue engineering

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