Generating structure-function correlations by ICA- based mapping of activation patterns on co-registered fMRI and FA-DTI data

S. Mitra, M. O'Boyle, E. Corona, B. Li, F. Afrin, B. Nutter, M. Baker, R. Pal, B. Ghosh, T. Karp

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) are noninvasive neuroimaging technologies providing functional mapping of stimulus activated voxels and detailed connectivity structures in the brain, which are traditionally based on simplified linear models. Despite the unique functional and structural representations achievable by fMRI and DTI, respectively, both representations still need validations of the assumptions embedded in the analysis of the data. Recent research efforts emphasize either a data driven or a hybrid approach to fMRI data analysis for more robust characterization of the data. Here we propose a methodology for finding relatively quantitative axonal connectivity pathways among distinct functional regions in the brain using appropriate image analysis techniques with the ultimate goal of generating a multidimensional structure-function correlation map. To achieve this goal, in our preliminary studies we have used independent component analysis (ICA) on fMRI data to locate the terminal seed points on axonal pathways segmented from fractional anisotropic (FA) DTI slices. The co-registered fMRI, and FA-DTI data with the corresponding anatomical image were color coded for visualization. A robust segmentation of axonal pathways was obtained by using a nonparametric estimation of Gaussian mixture model based on the transformation and analysis of the D(R) (distortion-rate) curve.

Original languageEnglish
Title of host publication2008 42nd Asilomar Conference on Signals, Systems and Computers, ASILOMAR 2008
Pages1393-1396
Number of pages4
DOIs
StatePublished - 2008
Event2008 42nd Asilomar Conference on Signals, Systems and Computers, ASILOMAR 2008 - Pacific Grove, CA, United States
Duration: Oct 26 2008Oct 29 2008

Publication series

NameConference Record - Asilomar Conference on Signals, Systems and Computers
ISSN (Print)1058-6393

Conference

Conference2008 42nd Asilomar Conference on Signals, Systems and Computers, ASILOMAR 2008
CountryUnited States
CityPacific Grove, CA
Period10/26/0810/29/08

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    Mitra, S., O'Boyle, M., Corona, E., Li, B., Afrin, F., Nutter, B., Baker, M., Pal, R., Ghosh, B., & Karp, T. (2008). Generating structure-function correlations by ICA- based mapping of activation patterns on co-registered fMRI and FA-DTI data. In 2008 42nd Asilomar Conference on Signals, Systems and Computers, ASILOMAR 2008 (pp. 1393-1396). [5074648] (Conference Record - Asilomar Conference on Signals, Systems and Computers). https://doi.org/10.1109/ACSSC.2008.5074648