Abstract
A novel method for Fmoc/tBu solution-phase peptide synthesis and the
development of a new benzyl-type group-assisted purification (GAP)
protecting group is reported. This GAP protecting group is utilized in
place of a polymer support, facilitating C -> N Fmoc peptide synthesis
without chroma tography or recrystallization. The GAP group can be added
and removed in high yield, and was used to synthesize over 1 gram of the
immunostimulant, thymopentin, in high overall yield (83 %) and purity
(99 %).
Original language | English |
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Pages (from-to) | 1714-1719 |
Journal | European Journal of Organic Chemistry |
State | Published - Mar 2016 |