Gait performance in relation to aortic pulse wave velocity, carotid artery elasticity, and peripheral perfusion in healthy older adults

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Abstract

Arterial stiffening is a widely known physiological change that occurs with aging, but the functional consequences of vascular aging is unclear. The purpose of this study was to determine if carotid-femoral pulse wave velocity (PWV), mechanical properties of the carotid and femoral arteries, and/or peripheral perfusion was associated with gait performance measured using a 400 m walk test. Twenty-one healthy older (68 ± 5 yrs) adults without cardiovascular disease participated in this study. Applanation tonometry was used to measure PWV and Doppler ultrasound was used to measure arterial wall properties of the left common carotid and common femoral artery along with femoral blood flow. The median walk distance in the first 2 min of the test was 585 ft and the overall gait speed was 1.5 m/s. Gait performance was inversely correlated with PWV (distance: r=-0.51; speed: r=-0.48; P < 0.05) and carotid artery stiffness index β (distance: r=-0.56; speed: r=-0.51; P < 0.05) after adjustm
Original languageEnglish
Pages (from-to)245-251
JournalClinical Physiology and Functional Imaging
DOIs
StatePublished - May 22 2013

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