Fronto-parietal activation in attention-deficit hyperactivity disorder, combined type: Functional magnetic resonance imaging study

T. Silk, A. Vance, N. Rinehart, G. Egan, M. O'Boyle, J. L. Bradshaw, R. Cunnington

Research output: Contribution to journalArticlepeer-review

113 Scopus citations

Abstract

A functional magnetic resonance imaging mental rotation paradigm was used to investigate the patterns of activation of fronto-parietal brain areas in male adolescents with attention-deficit hyperactivity disorder, combined type (ADHD-CT) compared with age-, gender-, handedness- and performance IQ-matched healthy controls. The ADHD-CT group had (a) decreased activation of the 'action-attentional' system (including Brodmann's areas (BA) 46, 39, 40) and the superior parietal (BA7) and middle frontal (BA10) areas and (b) increased activation of the posterior midline attentional system. These different neuroactivation patterns indicate widespread frontal, striatal and parietal dysfunction in adolescents with ADHD-CT.

Original languageEnglish
Pages (from-to)282-283
Number of pages2
JournalBritish Journal of Psychiatry
Volume187
Issue numberSEPT.
DOIs
StatePublished - Sep 2005

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