TY - JOUR
T1 - Fluid mechanics of heart valves
AU - Yoganathan, Ajit P.
AU - He, Zhaoming
AU - Jones, S. Casey
PY - 2004
Y1 - 2004
N2 - Valvular heart disease is a life-threatening disease that afflicts millions of people worldwide and leads to approximately 250,000 valve repairs and/or replacements each year. Malfunction of a native valve impairs its efficient fluid mechanic/hemodynamic performance. Artificial heart valves have been used since 1960 to replace diseased native valves and have saved millions of lives. Unfortunately, despite four decades of use, these devices are less than ideal and lead to many complications. Many of these complications/problems are directly related to the fluid mechanics associated with the various mechanical and bioprosthetic valve designs. This review focuses on the state-of-the-art experimental and computational fluid mechanics of native and prosthetic heart valves in current clinical use. The fluid dynamic performance characteristics of caged-ball, tilting-disc, bileaflet mechanical valves and porcine and pericardial stented and nonstented bioprostheic valves are reviewed. Other issues related to heart valve performance, such as biomaterials, solid mechanics, tissue mechanics, and durability, are not addressed in this review.
AB - Valvular heart disease is a life-threatening disease that afflicts millions of people worldwide and leads to approximately 250,000 valve repairs and/or replacements each year. Malfunction of a native valve impairs its efficient fluid mechanic/hemodynamic performance. Artificial heart valves have been used since 1960 to replace diseased native valves and have saved millions of lives. Unfortunately, despite four decades of use, these devices are less than ideal and lead to many complications. Many of these complications/problems are directly related to the fluid mechanics associated with the various mechanical and bioprosthetic valve designs. This review focuses on the state-of-the-art experimental and computational fluid mechanics of native and prosthetic heart valves in current clinical use. The fluid dynamic performance characteristics of caged-ball, tilting-disc, bileaflet mechanical valves and porcine and pericardial stented and nonstented bioprostheic valves are reviewed. Other issues related to heart valve performance, such as biomaterials, solid mechanics, tissue mechanics, and durability, are not addressed in this review.
KW - Bioprosthetic valves
KW - Computational fluid dynamics
KW - Laser Doppler velocimetry
KW - Mechanical heart valves
KW - Native heart valves
UR - http://www.scopus.com/inward/record.url?scp=4444375110&partnerID=8YFLogxK
U2 - 10.1146/annurev.bioeng.6.040803.140111
DO - 10.1146/annurev.bioeng.6.040803.140111
M3 - Review article
C2 - 15255773
AN - SCOPUS:4444375110
VL - 6
SP - 331
EP - 362
JO - Annual Review of Biomedical Engineering
JF - Annual Review of Biomedical Engineering
SN - 1523-9829
ER -