TY - JOUR
T1 - Flowing atmospheric-pressure afterglow drift tube ion mobility spectrometry
AU - Latif, Mohsen
AU - Zhang, Dong
AU - Gamez, Gerardo
N1 - Funding Information:
The authors would like to thank Scott Hiemstra at the TTU Dept. of Chemistry and Biochemistry Machine Shop. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/6/8
Y1 - 2021/6/8
N2 - In this work, the flowing atmospheric-pressure afterglow (FAPA) ambient desorption/ionization source has been coupled with stand-alone Drift Tube Ion Mobility Spectrometry (DTIMS) for the first time. A tip repeller electrode, modified to allow higher bias potential still below the Townsend's breakdown, was implemented at the FAPA/DTIMS interface to overcome the opposing potentials and facilitate ion transmission. The effect of the lab-built DTIMS and FAPA's operating conditions (such as plasma voltage, current, gas flow rate, repeller's potential and positioning, FAPA orientation, etc.) on the signal of selected analytes was studied, for both gas-phase injection and desorption. The FAPA reactant ion peak (RIP) reduced mobility coefficient (K0) corresponds to protonated water clusters (H2O)nH+. The FAPA-DTIMS spectra of several selected compounds showed that their K0 agrees with literature values. Moreover, quantitative characterization of acetaminophen and 2,6-di-tert-butylpyridine (2,6-DTBP) based on desorption or gas-phase injection yield limits of detection (LODs) of 0.03 μg and 18 ppb, respectively.
AB - In this work, the flowing atmospheric-pressure afterglow (FAPA) ambient desorption/ionization source has been coupled with stand-alone Drift Tube Ion Mobility Spectrometry (DTIMS) for the first time. A tip repeller electrode, modified to allow higher bias potential still below the Townsend's breakdown, was implemented at the FAPA/DTIMS interface to overcome the opposing potentials and facilitate ion transmission. The effect of the lab-built DTIMS and FAPA's operating conditions (such as plasma voltage, current, gas flow rate, repeller's potential and positioning, FAPA orientation, etc.) on the signal of selected analytes was studied, for both gas-phase injection and desorption. The FAPA reactant ion peak (RIP) reduced mobility coefficient (K0) corresponds to protonated water clusters (H2O)nH+. The FAPA-DTIMS spectra of several selected compounds showed that their K0 agrees with literature values. Moreover, quantitative characterization of acetaminophen and 2,6-di-tert-butylpyridine (2,6-DTBP) based on desorption or gas-phase injection yield limits of detection (LODs) of 0.03 μg and 18 ppb, respectively.
KW - Ambient desorption/ionization
KW - Direct solid analysis
KW - Drift tube ion mobility spectrometry
KW - Flowing atmospheric-pressure afterglow
KW - Nitrogen plasma gas
KW - Tip repeller electrode coupling
UR - http://www.scopus.com/inward/record.url?scp=85104405272&partnerID=8YFLogxK
U2 - 10.1016/j.aca.2021.338507
DO - 10.1016/j.aca.2021.338507
M3 - Article
C2 - 34024423
AN - SCOPUS:85104405272
VL - 1163
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
SN - 0003-2670
M1 - 338507
ER -