TY - JOUR
T1 - Flight muscle carnitine palmitoyl transferase activity varies with substrate chain length and unsaturation in the hoary bat, Lasiurus cinereus
AU - Price, Edwin R
AU - McGuire, Liam
AU - Fenton, M Brock
AU - Guglielmo, Christopher G
PY - 2014/2
Y1 - 2014/2
N2 - Fat is an important fuel for bats to support high metabolic rates in extended periods of flight. The fatty acid
composition of adipose stores could affect whole animal exercise performance, as fatty acids vary in rates of mobilization
and oxidation. A key step in the fatty acid oxidation pathway is transporting fatty acids from the cytosol into mitochondria,
mediated by the enzyme carnitine palmitoyl transferase (CPT). Therefore, understanding the substrate preference patterns
of CPT in bats is important for interpreting the consequences of adipose fatty acid profiles. We measured CPT activity with
eight different fatty acyl CoA substrates (16:0, 16:17, 18:0, 18:19, 18:26, 18:33, 20:46, and 22:63) in the pectoralis
muscle of migrating and nonmigrating hoary bats (Lasiurus cinereus (Beauvois, 1796)). The pattern of substrate preference
was similar to the patterns previously reported for birds and rats and was not affected by migration. Generally, activity
increased with the number of d
AB - Fat is an important fuel for bats to support high metabolic rates in extended periods of flight. The fatty acid
composition of adipose stores could affect whole animal exercise performance, as fatty acids vary in rates of mobilization
and oxidation. A key step in the fatty acid oxidation pathway is transporting fatty acids from the cytosol into mitochondria,
mediated by the enzyme carnitine palmitoyl transferase (CPT). Therefore, understanding the substrate preference patterns
of CPT in bats is important for interpreting the consequences of adipose fatty acid profiles. We measured CPT activity with
eight different fatty acyl CoA substrates (16:0, 16:17, 18:0, 18:19, 18:26, 18:33, 20:46, and 22:63) in the pectoralis
muscle of migrating and nonmigrating hoary bats (Lasiurus cinereus (Beauvois, 1796)). The pattern of substrate preference
was similar to the patterns previously reported for birds and rats and was not affected by migration. Generally, activity
increased with the number of d
KW - Carnitine acyl-transferase
KW - Carnitine palmitoyl transferase
KW - Fatty acid composition
KW - Hoary bat
KW - Lasiurus cinereus
KW - Lipid oxidation
UR - http://www.scopus.com/inward/record.url?scp=84893432867&partnerID=8YFLogxK
U2 - 10.1139/cjz-2013-0141
DO - 10.1139/cjz-2013-0141
M3 - Article
SN - 0008-4301
VL - 92
SP - 173
EP - 176
JO - Canadian Journal of Zoology
JF - Canadian Journal of Zoology
IS - 2
ER -