First and Corresponding Author

Shaikh Rahman, Mahua Choudhury, Rachel C Janssen, Karalee C Baquero, Makoto Miyazaki, Jed Friedman

Research output: Contribution to journalArticle

Abstract

Drugs designed specifically to activate liver X receptors (LXRs) have beneficial effects on lowering cholesterol metabolism and inflammation but unfortunately lead to severe hepatic steatosis. The transcription factor CCAAT/enhancer binding protein beta (C/EBPb) is an important regulator of liver gene expression but little is known about its involvement in LXR-based steatosis and cholesterol metabolism. The present study investigated the role of C/EBPb expression in LXR agonist (T0901317)-mediated alteration of hepatic triglyceride (TG) and lipogenesis in mice. C/EBPb deletion in mice prevented LXR agonist-mediated induction of lipogenic gene expression in liver in conjunction with significant reduction of liver TG accumulation. Surprisingly, C/EBPb_/_ mice showed a major increase in liver mitochondrial electron chain function compared to WT mice. Furthermore, LXR activation in C/EBPb_/_ mice increased the expression of liver ATP-binding cassette transporter ABCG1, a gene implicated i
Original languageEnglish
Pages (from-to)336-339
JournalElsevier
StatePublished - Jan 2013

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    Rahman, S., Choudhury, M., Janssen, R. C., Baquero, K. C., Miyazaki, M., & Friedman, J. (2013). First and Corresponding Author. Elsevier, 336-339.