First and Corresponding Author

Shaikh Rahman; Mahua Choudhury; Rachel C Janssen; Karalee C Baquero; Makoto Miyazaki; Jed Friedman

First and Corresponding Author

Shaikh Rahman, Mahua Choudhury, Rachel C Janssen, Karalee C Baquero, Makoto Miyazaki, Jed Friedman

Mechanical Engineering

Research output: Contribution to journal › Article

Abstract

Drugs designed specifically to activate liver X receptors (LXRs) have beneficial effects on lowering cholesterol metabolism and inflammation but unfortunately lead to severe hepatic steatosis. The transcription factor CCAAT/enhancer binding protein beta (C/EBPb) is an important regulator of liver gene expression but little is known about its involvement in LXR-based steatosis and cholesterol metabolism. The present study investigated the role of C/EBPb expression in LXR agonist (T0901317)-mediated alteration of hepatic triglyceride (TG) and lipogenesis in mice. C/EBPb deletion in mice prevented LXR agonist-mediated induction of lipogenic gene expression in liver in conjunction with significant reduction of liver TG accumulation. Surprisingly, C/EBPb_/_ mice showed a major increase in liver mitochondrial electron chain function compared to WT mice. Furthermore, LXR activation in C/EBPb_/_ mice increased the expression of liver ATP-binding cassette transporter ABCG1, a gene implicated i

Original language	English
Pages (from-to)	336-339
Journal	Elsevier
State	Published - Jan 2013

Cite this

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title = "First and Corresponding Author",

abstract = "Drugs designed specifically to activate liver X receptors (LXRs) have beneficial effects on lowering cholesterol metabolism and inflammation but unfortunately lead to severe hepatic steatosis. The transcription factor CCAAT/enhancer binding protein beta (C/EBPb) is an important regulator of liver gene expression but little is known about its involvement in LXR-based steatosis and cholesterol metabolism. The present study investigated the role of C/EBPb expression in LXR agonist (T0901317)-mediated alteration of hepatic triglyceride (TG) and lipogenesis in mice. C/EBPb deletion in mice prevented LXR agonist-mediated induction of lipogenic gene expression in liver in conjunction with significant reduction of liver TG accumulation. Surprisingly, C/EBPb_/_ mice showed a major increase in liver mitochondrial electron chain function compared to WT mice. Furthermore, LXR activation in C/EBPb_/_ mice increased the expression of liver ATP-binding cassette transporter ABCG1, a gene implicated i",

author = "Shaikh Rahman and Mahua Choudhury and Janssen, {Rachel C} and Baquero, {Karalee C} and Makoto Miyazaki and Jed Friedman",

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month = jan,

language = "English",

pages = "336--339",

journal = "Elsevier",

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TY - JOUR

T1 - First and Corresponding Author

AU - Rahman, Shaikh

AU - Choudhury, Mahua

AU - Janssen, Rachel C

AU - Baquero, Karalee C

AU - Miyazaki, Makoto

AU - Friedman, Jed

PY - 2013/1

Y1 - 2013/1

N2 - Drugs designed specifically to activate liver X receptors (LXRs) have beneficial effects on lowering cholesterol metabolism and inflammation but unfortunately lead to severe hepatic steatosis. The transcription factor CCAAT/enhancer binding protein beta (C/EBPb) is an important regulator of liver gene expression but little is known about its involvement in LXR-based steatosis and cholesterol metabolism. The present study investigated the role of C/EBPb expression in LXR agonist (T0901317)-mediated alteration of hepatic triglyceride (TG) and lipogenesis in mice. C/EBPb deletion in mice prevented LXR agonist-mediated induction of lipogenic gene expression in liver in conjunction with significant reduction of liver TG accumulation. Surprisingly, C/EBPb_/_ mice showed a major increase in liver mitochondrial electron chain function compared to WT mice. Furthermore, LXR activation in C/EBPb_/_ mice increased the expression of liver ATP-binding cassette transporter ABCG1, a gene implicated i

AB - Drugs designed specifically to activate liver X receptors (LXRs) have beneficial effects on lowering cholesterol metabolism and inflammation but unfortunately lead to severe hepatic steatosis. The transcription factor CCAAT/enhancer binding protein beta (C/EBPb) is an important regulator of liver gene expression but little is known about its involvement in LXR-based steatosis and cholesterol metabolism. The present study investigated the role of C/EBPb expression in LXR agonist (T0901317)-mediated alteration of hepatic triglyceride (TG) and lipogenesis in mice. C/EBPb deletion in mice prevented LXR agonist-mediated induction of lipogenic gene expression in liver in conjunction with significant reduction of liver TG accumulation. Surprisingly, C/EBPb_/_ mice showed a major increase in liver mitochondrial electron chain function compared to WT mice. Furthermore, LXR activation in C/EBPb_/_ mice increased the expression of liver ATP-binding cassette transporter ABCG1, a gene implicated i

M3 - Article

SP - 336

EP - 339

JO - Elsevier

JF - Elsevier

ER -

First and Corresponding Author

Abstract

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