TY - JOUR
T1 - Feasibility of using negative pressure for jet injection applications
AU - Rane, Yatish S.
AU - Thomas, James B.
AU - Fisher, Paul
AU - Broderick, Kate E.
AU - Marston, Jeremy O.
N1 - Funding Information:
This work was financially supported by Inovio Pharmaceuticals and National Science Foundation via award number NSF-CBET-1749382 .
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/6
Y1 - 2021/6
N2 - We report on an experimental study of high-speed micro-scale liquid jets ejected into low-pressure environments, which has applications for the use of negative pressure modules in jet injector systems. The jets were impulsively started by the action of a stiff spring-piston and ejected through a narrow orifice, D0 ~ 100 μm, into partial vacuums ranging from atmospheric pressure down to −80 kPa. We find that due to the high exit velocity, vj ~ 100 m/s, the main jet stream is largely unaffected, but we reveal some fascinating fine features during the start-up phase, largely due to the presence of a small liquid volume pulled through the orifice prior to actuating the jet. In particular, as the pressure decreases, the start-up time increases and the initial spray becomes more pronounced. However, the primary outcome of this feasibility study is that use of negative pressures is viable for jet injector applications, and we hypothesize an optimal range of working pressures and configurations.
AB - We report on an experimental study of high-speed micro-scale liquid jets ejected into low-pressure environments, which has applications for the use of negative pressure modules in jet injector systems. The jets were impulsively started by the action of a stiff spring-piston and ejected through a narrow orifice, D0 ~ 100 μm, into partial vacuums ranging from atmospheric pressure down to −80 kPa. We find that due to the high exit velocity, vj ~ 100 m/s, the main jet stream is largely unaffected, but we reveal some fascinating fine features during the start-up phase, largely due to the presence of a small liquid volume pulled through the orifice prior to actuating the jet. In particular, as the pressure decreases, the start-up time increases and the initial spray becomes more pronounced. However, the primary outcome of this feasibility study is that use of negative pressures is viable for jet injector applications, and we hypothesize an optimal range of working pressures and configurations.
KW - Liquid jet
KW - Needle-free injection
KW - Negative pressure
UR - http://www.scopus.com/inward/record.url?scp=85101119926&partnerID=8YFLogxK
U2 - 10.1016/j.jddst.2021.102395
DO - 10.1016/j.jddst.2021.102395
M3 - Article
AN - SCOPUS:85101119926
SN - 1773-2247
VL - 63
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
M1 - 102395
ER -