TY - JOUR
T1 - Facile synthesis of benzo[
T2 - B] thiophenes via metal-free radical-triggered intramolecular C-S bond formation
AU - Fan, Wei
AU - Chen, Kwong Yuen
AU - Chen, Qi Peng
AU - Li, Guigen
AU - Jiang, Bo
N1 - Funding Information:
We are grateful to the NSFC (No. 21332005 and 21672100), the Robert A. Welch Foundation (D-1361, USA), the PAPD of Jiangsu Higher Education Institutions, and the NSF of Jiangsu Province (BK20151163) for financial support.
Publisher Copyright:
© 2017 The Royal Society of Chemistry.
PY - 2017
Y1 - 2017
N2 - A facile method for the synthesis of benzo[b]thiophenes with good to excellent yields via metal-free intramolecular C-S bond formation has been developed by utilizing I2 as a catalyst and O2 from air as an oxidant (20 examples). Its notable features such as catalytic I2, intramolecular C-S bond formation, short reaction times, and broad functional group tolerance make this strategy highly attractive. The purification of products only needs washing with solvents, thereby avoiding traditional chromatography and recrystallization, which belongs to group-assisted purification (GAP) chemistry.
AB - A facile method for the synthesis of benzo[b]thiophenes with good to excellent yields via metal-free intramolecular C-S bond formation has been developed by utilizing I2 as a catalyst and O2 from air as an oxidant (20 examples). Its notable features such as catalytic I2, intramolecular C-S bond formation, short reaction times, and broad functional group tolerance make this strategy highly attractive. The purification of products only needs washing with solvents, thereby avoiding traditional chromatography and recrystallization, which belongs to group-assisted purification (GAP) chemistry.
UR - http://www.scopus.com/inward/record.url?scp=85027248068&partnerID=8YFLogxK
U2 - 10.1039/c7ob01515a
DO - 10.1039/c7ob01515a
M3 - Article
C2 - 28745373
AN - SCOPUS:85027248068
VL - 15
SP - 6493
EP - 6499
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
SN - 1477-0520
IS - 31
ER -