Facile synthesis of benzo[: B] thiophenes via metal-free radical-triggered intramolecular C-S bond formation

Wei Fan, Kwong Yuen Chen, Qi Peng Chen, Guigen Li, Bo Jiang

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A facile method for the synthesis of benzo[b]thiophenes with good to excellent yields via metal-free intramolecular C-S bond formation has been developed by utilizing I2 as a catalyst and O2 from air as an oxidant (20 examples). Its notable features such as catalytic I2, intramolecular C-S bond formation, short reaction times, and broad functional group tolerance make this strategy highly attractive. The purification of products only needs washing with solvents, thereby avoiding traditional chromatography and recrystallization, which belongs to group-assisted purification (GAP) chemistry.

Original languageEnglish
Pages (from-to)6493-6499
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume15
Issue number31
DOIs
StatePublished - 2017

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