Fabrication of aligned nanofibers along Z-axis - A novel 3D Electrospinning technique

George Z. Tan, Yingge Zhou

Research output: Contribution to conferencePaperpeer-review

Abstract

This study presents a 3D fabrication technique of nanofibrous scaffold for tissue engineering. A divergence static electric field was introduced in an electrospinning system to induce a self-assembly of aligned nanofibers into a tunable 3D architecture with thickness ranging from 2-12 mm. The effects of collector configuration on polycaprolactone (PCL) nanofiber attributes were investigated. Human fibroblast cells were cultured on the nanofiber scaffold in vitro for 7 days. It was found that the width and inclination angle of the collector influenced the nanofiber density distribution. The cells proliferated on the scaffold and organized as a fibrous matrix which mimicked the microstructure of native musculoskeletal tissues.

Original languageEnglish
Pages2396-2404
Number of pages9
StatePublished - 2020
Event29th Annual International Solid Freeform Fabrication Symposium - An Additive Manufacturing Conference, SFF 2018 - Austin, United States
Duration: Aug 13 2018Aug 15 2018

Conference

Conference29th Annual International Solid Freeform Fabrication Symposium - An Additive Manufacturing Conference, SFF 2018
CountryUnited States
CityAustin
Period08/13/1808/15/18

Keywords

  • 3D nanofiber scaffold
  • Divergence electrospinning
  • Tissue engineering

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