Abstract
Metabolic Control Theory (MCT) has been thoroughly developed for the analysis of enzymatic reactions. MCT has also been applied to non-enzymatic systems such as chemostats and electron transport chains. Due to the analogous expressions for calcium transport and enzyme kinetics we propose that MCT is applicable to calcium handling in cardiac myocytes. This theory is further substantiated by Kacser and Burns' statement that MCT is applicable to systems of any complexity or kinetics. This proposition is investigated through comparison of computer calculated control coefficients with control coefficients determined experimentally. The use of the summation theorems for analysis validation, to ensure that all controlling parameters have been accounted for, is investigated. We report the success of these investigations qualitatively and quantitatively.
| Original language | English |
|---|---|
| Pages (from-to) | 2219-2220 |
| Number of pages | 2 |
| Journal | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Volume | 3 |
| State | Published - 2002 |
| Event | Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States Duration: Oct 23 2002 → Oct 26 2002 |
Keywords
- Calcium transport
- Cardiac myocyte
- MCT
- Summation theorem