Expression of somatostatin receptor mRNAs is regulated in vivo by growth hormone, insulin, and insulin-like growth factor-I in rainbow trout (Oncorhynchus mykiss)

Barton J. Slagter, Jeffrey Kittilson, Mark A. Sheridan

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Somatostatins are a diverse family of peptide hormones that regulate various aspects of growth, development, and metabolism through interactions with numerous somatostatin receptor subtypes (SSTRs) on target tissues. In this study, we used rainbow trout to evaluate the effects of growth hormone (GH), insulin (INS), and insulin-like growth factor-I (IGF-I) on the expression of SSTR 1A, 1B and 2 mRNAs. GH regulated the expression of SSTRs in a subtype- and tissue-specific manner. GH reduced SSTR 1A, 1B, and 2 expression in optic tectum, reduced SSTR 1A and 1B expression in pancreas, reduced SSTR 1A expression in liver, and increased hepatic SSTR 1B expression. INS also regulated SSTR expression in a subtype- and tissue-specific manner. INS reduced SSTR 1B expression in optic tectum, increased SSTR 2 expression in pancreas, and increased SSTR 1B and 2 expression in liver. IGF-I generally decreased the expression of all SSTRs. These data indicate that GH, INS, and IGF-I modulate the expression of SSTRs and suggest that independent mechanisms may serve to regulate the various receptor subtypes.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalRegulatory Peptides
Volume128
Issue number1
DOIs
StatePublished - May 15 2005

Keywords

  • Real-time quantitative PCR
  • Somatostatin receptor expression
  • Somatostatin receptor subtype 1A
  • Somatostatin receptor subtype 1B
  • Somatostatin receptor subtype 2

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