Exposure to hazardous substances and male reproductive health: a research framework

J. M. Moline, A. L. Golden, Ernest Smith, M. E. Rauch, R. E. Chapin, S. D. Perreault, S. M. Schrader, W. A. Suk, P J. Landrigan

Research output: Contribution to journalArticle


The discovery in the mid-1970s that occupational exposures to pesticides could diminish or destroy the fertility of workers sparked concern about the effects of hazardous substances on male reproductive health. More recently, there is evidence that sperm quantity and quality may have declined worldwide, that the incidence of testicular cancer has progressively increased in many countries, and that other disorders of the male reproductive tract such as hypospadias and cryptorchidism may have also increased. There is growing concern that occupational factors and environmental chemical exposures, including in utero and childhood exposures to compounds with estrogenic activity, may be correlated with these observed changes in male reproductive health and fertility. We review the evidence and methodologies that have contributed to our current understanding of environmental effects on male reproductive health and fertility and discuss the methodologic issues which confront investigators in
Original languageEnglish
Pages (from-to)803-13
JournalEnviron Health Perspect
StatePublished - Oct 6 2001


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