Paraffins, specifically alkanes, promotes asphaltene precipitation when they are blended with asphaltene-containing petroleum fluids. The alkane/oil volume ratio required for onset of asphaltene precipitation increases with the carbon number and yields a maxima. Experimental study indicates that the maxima lays at C7 or between C8 - C10 , However, precipitation yield decreases asymptotically with increase of the carbon number even if excessively high alkane/oil volume ratio is used , For example, n-pentane be a better solvent for asphaltene than n-hexane in regard of both onset of precipitation and precipitation yield. However, high carbon number alkane beyond the maxima, n-hexadecane for instance, can be a better solvent at onset of precipitation point and a poorer solvent in regard of precipitation yield than n-pentadecane. A thermodynamic explanation for this paradox is necessarily important to find the compatibility of bitumen or crude oil with paraffinic hydrocarbons. In this work, this paradox is explained by the aggregation thermodynamics of asphaltene precipitation , Both the enthalpy and entropy of mixing are investigated to explain the effect of paraffin carbon number on asphaltene precipitation. Athabasca and cold lake bitumen samples are studied.