In recent years attempts have been made to use packed towers for regenerating weak liquid desiccants in desiccant cooling or drying processes. For regeneration of desiccants, a counterflow packed regeneration tower in conjunction with a humidifier has been designed and constructed. The tower was packed with plastic Intalox Snowflake packing material. Experimental measurements of the regeneration tower performance utilizing a new cost effective liquid desiccant mixture CELD (comprised of 50% of lithium chloride and 50% calcium chloride by weight) have been carried out. The average summer climatic conditions for Oklahoma (dry-bulb temperature of 90°F and relative humidity of 60%), Texas (dry-bulb temperature of 90°F and relative humidity of 70%), and Florida (dry-bulb temperature of 90°F and relative humidity of 80%) were simulated with air inlet condition to the tower. The effect of desiccant inlet temperature, inlet concentration, and flow rate on the regeneration tower performance has been investigated.