Exercise-induced vasodilation is associated with menopause stage in healthy middle-aged women

David J. Moore, Joaquin Gonzales, Steven H. Tucker, Steriani Elavsky, David N. Proctor

Research output: Contribution to journalArticlepeer-review


Objective: To determine whether leg exercise hemodynamic responses are menopause stage-dependent in healthy, middle-aged women. Methods: Women were divided into early perimenopausal (n = 16), late perimenopausal (n = 12), and early postmenopausal (n=11) groups based on self-reported bleeding history using the Stages of Reproductive Aging Workshop (STRAW) criteria. Femoral artery blood flow (FBF), mean arterial pressure (MAP), and femoral vascular conductance (FVC) were measured during graded single-leg knee extensor exercise. Results: FBF and FVC at rest and during very light work rates (0 and 5 Watts) were similar among all three menopause stage groups. At 10 Watts, FBF and FVC were significantly higher (P < 0.05) in early perimenopausal compared with late perimenopausal women At higher work rates (15-25 Watts) FBF and FVC were similar between late perimenopausal and early postmenopausal groups, but higher (P<0.05) in early perimenopausal women as compared with the other two
Original languageEnglish
Pages (from-to)418-424
JournalApplied Physiology, Nutrition and Metabolism
StatePublished - Apr 2012


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