TY - JOUR
T1 - Examining Prefrontal Cortex Activity and Tonic Anxiety in Alcohol Use Disorder Recovery
T2 - A Functional Near Infrared Spectroscopy Study
AU - Wagner, Alison N.
AU - Bradshaw, Spencer D.
AU - Dawson, John A.
AU - Shumway, Sterling T.
N1 - Publisher Copyright:
© 2017 Taylor & Francis.
PY - 2017/7/3
Y1 - 2017/7/3
N2 - Cognitive impairment, emotional reactivity, and circuitry differences have been examined for anxiety using functional magnetic resonance imaging, positron emission tomography, and near infrared spectroscopy, with no overwhelming consensus as to the impacted brain regions. In the present study, 32 participants in recovery from alcohol use disorder were administered the Penn State Worry Questionnaire to assess tonic anxiety level and viewed aversive images during functional near infrared spectroscopy (fNIR) prefrontal cortex (PFC) assessment. Negative cue examination revealed a positive association between anxiety level and left dorsolateral and dorsomedial PFC activation. Previous alcoholism research demonstrates potential confounds in these dorsolateral and dorsomedial regions, limiting generalizations to addiction-naïve populations. However, fNIR presently showed reliability as an imaging technique for assessing anxiety-related PFC activity that could augment standard diagnostic procedures for anxiety disorders. In addition, this type of research could impact understanding of comorbidity in alcohol use disorder treatment and recovery.
AB - Cognitive impairment, emotional reactivity, and circuitry differences have been examined for anxiety using functional magnetic resonance imaging, positron emission tomography, and near infrared spectroscopy, with no overwhelming consensus as to the impacted brain regions. In the present study, 32 participants in recovery from alcohol use disorder were administered the Penn State Worry Questionnaire to assess tonic anxiety level and viewed aversive images during functional near infrared spectroscopy (fNIR) prefrontal cortex (PFC) assessment. Negative cue examination revealed a positive association between anxiety level and left dorsolateral and dorsomedial PFC activation. Previous alcoholism research demonstrates potential confounds in these dorsolateral and dorsomedial regions, limiting generalizations to addiction-naïve populations. However, fNIR presently showed reliability as an imaging technique for assessing anxiety-related PFC activity that could augment standard diagnostic procedures for anxiety disorders. In addition, this type of research could impact understanding of comorbidity in alcohol use disorder treatment and recovery.
KW - Anxiety
KW - alcohol use disorder
KW - aversive cues
KW - cue reactivity
KW - fNIR
KW - prefrontal cortex
UR - http://www.scopus.com/inward/record.url?scp=85020640271&partnerID=8YFLogxK
U2 - 10.1080/07347324.2017.1322422
DO - 10.1080/07347324.2017.1322422
M3 - Article
AN - SCOPUS:85020640271
SN - 0734-7324
VL - 35
SP - 243
EP - 259
JO - Alcoholism Treatment Quarterly
JF - Alcoholism Treatment Quarterly
IS - 3
ER -