Examining PFC activity and Tonic Anxiety in Alcohol Use Disorder Recovery: a Functional Near Infrared Spectroscopy Study.

Alison Wagner, Spencer Bradshaw, John Dawson, Sterling Shumway

Research output: Contribution to journalArticle

Abstract

Objective: Cognitive impairment, emotional reactivity, and circuitry differences have been examined for anxiety using Functional Magnetic Resonance Imaging, Positron Emission Tomography, and Near Infrared Spectroscopy, with no overwhelming consensus as to the impacted brain regions. Methods: In the present study, thirty-two participants with a history of alcoholism were administered the Penn State Worry Questionnaire to assess tonic anxiety level and viewed aversive images during Functional Near Infrared Spectroscopy (fNIR) prefrontal cortex (PFC) assessment. Results: Negative cue examination revealed a positive association between anxiety level and left dorsolateral and dorsomedial PFC activation. Conclusion: Previous alcoholism research demonstrates potential confounds in these dorsolateral and dorsomedial regions, limiting generalizations to addiction-naïve populations. However, fNIR presently showed reliability as an imaging technique for assessing anxiety-related PFC activity tha
Original languageEnglish
Pages (from-to)243-259
JournalAlcoholism Treatment Quarterly
StatePublished - Jun 9 2017

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