Evolution dynamics of pore sizes, cell volume, ionic concentrations following high-voltage pulsing

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Abstract

Model studies are presented for nanopore dynamics of cells subjected to high-intensity voltage pulsing. The role of concentration differences leading to osmotic flows, cell-size modulation, and resulting stresses on the plasma membrane are all comprehensively probed. Our results show that the life span of pores can either be short or very long depending on various conditions. Our model results are consistent with recent experimental observations and suggest that nanopores with a larger radius would tend to evolve into long-lived metastable entities. This has obvious implications to both drug delivery and gene transfer.

Original languageEnglish
Article number6156794
Pages (from-to)2355-2359
Number of pages5
JournalIEEE Transactions on Plasma Science
Volume40
Issue number10 PART 1
DOIs
StatePublished - 2012

Keywords

  • Modeling
  • Pore lifetimes
  • Voltage pulsing
  • vElectroporation

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