Evidence for the emergence of leg sympathetic vasoconstrictor tone with age in healthy women

David J. Moore, Matthew A. Barlow, Joaquin U. Gonzales, Cheri L. McGowan, James A. Pawelczyk, David N. Proctor

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


While muscle sympathetic nerve activity (MSNA) is elevated with advancing age, correlational evidence suggests that, in contrast to men, basal MSNA is not related to resting lower limb hemodynamics in women. However, limited data exists in women that have attempted to directly assess the degree of limb sympathetic vasoconstrictor tone, and whether it is altered with age. To address this issue, we measured changes in femoral artery vascular conductance (FVC) during an acute sympatho-inhibitory stimulus (‒60 mm Hg neck suction, NS) in groups of healthy younger (n = 8, 23 ± 1 years) and older (n = 7, 66 ± 1 years) women. The percent change in FVC in response to NS was significantly augmented in the older (P = 0.006 vs. young) women. Although NS caused no significant change (3 ± 3%, P = 0.33) in FVC in the young women, there was a robust increase in FVC (21 ± 5%, P = 0.003) in the old women. Collectively, these findings provide evidence that in women, leg sympathetic vasoconstrictor tone emerges with age.

Original languageEnglish
Article numbere12275
Pages (from-to)1-7
Number of pages7
JournalPhysiological Reports
Issue number1
StatePublished - 2015


  • Aging
  • Blood flow
  • Sympathetic
  • Vascular conductance


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