Evaluations of a mechanistic hypothesis for the influence of extracellular ions on electroporation due to high-intensity, nanosecond pulsing

V. Sridhara, R. P. Joshi

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The effect of ions present in the extracellular medium on electroporation by high-intensity, short-duration pulsing is studied through molecular dynamic simulations. Our simulation results indicate that mobile ions in the medium might play a role in creating stronger local electric fields across membranes that then reinforce and strengthen electroporation. Much faster pore formation is predicted in higher conductivity media. However, the impact of extracellular conductivity on cellular inflows, which depend on transport processes such as electrophoresis, could be different as discussed here. Our simulation results also show that interactions between cations (Na+ in this case) and the carbonyl oxygen of the lipid headgroups could impede pore resealing.

Original languageEnglish
Pages (from-to)1793-1800
Number of pages8
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1838
Issue number7
DOIs
StatePublished - Jul 2014

Keywords

  • Electric pulsing
  • Ions
  • Lipid
  • Molecular dynamics
  • Nanopore

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