Evaluation of the developmental toxicity of chlorinated phenols utilizing Hydra attenuata and postimplantation rat embryos in culture

K Mayura, Ernest Smith, B. A. Clement, T. D. Phillips

Research output: Contribution to journalArticle

Abstract

Chlorinated phenols (CPs) represent a major component of hazardous oily and wood-preserving wastes that are widely distributed in chemical dumpsites throughout the United States. Pentachlorophenol (C5P) has been reported to be highly embryolethal and embryotoxic in rats. However, data pertaining to the developmental toxicities of other important CPs are limited. In this study, the toxicities of phenol, CP homologues and their isomers, selected phenyl acetates, anisoles, sodium phenates, and tetrachlorobenzoquinones (a total of 38 chemicals) were evaluated using cultures of Hydra attenuata (HA). Developmental hazard index (A/D ratio) was determined for selected test chemicals (i.e., those chemicals which resulted in an early toxic endpoint at the lowest whole-log concentration in the adult hydra assay). These same chemicals were evaluated at equimolar concentration in postimplantation rat whole embryo culture (WEC). HA and WEC studies demonstrated a linear relationship between toxicity
Original languageEnglish
Pages (from-to)253-66
JournalToxicol Appl Pharmacol
StatePublished - Apr 1 1991

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