Evaluation of the anti-inflammatory, analgesic and anti-ulcerogenic potentials of Achillea fragrantissima (Forssk.)

R.F. Abdel-Rahman, S.I. Alqasoumi, A.H. El-Desoky, G.A. Soliman, Paul Pare, M.-E.F. Hegazy

Research output: Contribution to journalArticlepeer-review

Abstract

Achillea fragrantissima is a perennial herb grown in Egypt and traditionally employed medicinally for its anti-inflammatory and analgesic properties among Sinai inhabitants. Non-polar and polar extracts were obtained by successive foliar extraction with dichloromethane:methanol (1:1) and 70% aqueous methanol, respectively. Achillea extracts were assayed in rodents for anti-inflammatory, anti-ulcerogenic and analgesic activities. Materials and methods: Acute toxicity of non-polar and polar extracts of A. fragrantissima was evaluated in mice. Anti-inflammatory activity was assessed in carrageenan-induced rat-paw edema test while analgesic activity was explored centrally and peripherally using hot plate and writhing tests, respectively. In addition, antiulcerogenic activity was assayed in colon and gastric tissues. Foliar extracts of A. fragrantissima exhibited anti-inflammatory, central and peripheral analgesic activities. Moreover, both non-polar and polar fractions revealed protective
Original languageEnglish
Pages (from-to)122-127
JournalSA Journal of Botany
StatePublished - 2015

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