Evaluation of the anti-inflammatory, analgesic and anti-ulcerogenic potentials of Achillea fragrantissima (Forssk.)

R. F. Abdel-Rahman, S. I. Alqasoumi, A. H. El-Desoky, G. A. Soliman, P. W. Paré, M. E.F. Hegazy

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Achillea fragrantissima is a perennial herb grown in Egypt and traditionally employed medicinally for its anti-inflammatory and analgesic properties among Sinai inhabitants. Non-polar and polar extracts were obtained by successive foliar extraction with dichloromethane:methanol (1:1) and 70% aqueous methanol, respectively. Achillea extracts were assayed in rodents for anti-inflammatory, anti-ulcerogenic and analgesic activities. Materials and methods: Acute toxicity of non-polar and polar extracts of A. fragrantissima was evaluated in mice. Anti-inflammatory activity was assessed in carrageenan-induced rat-paw edema test while analgesic activity was explored centrally and peripherally using hot plate and writhing tests, respectively. In addition, anti-ulcerogenic activity was assayed in colon and gastric tissues. Results: Foliar extracts of A. fragrantissima exhibited anti-inflammatory, central and peripheral analgesic activities. Moreover, both non-polar and polar fractions revealed protective effects against rat ulcerative colitis and gastric ulcers. Conclusion: A. fragrantissima extracts possess anti-inflammatory, central and peripheral analgesic activities in addition to protective properties in colonic and gastric tissues.

Original languageEnglish
Pages (from-to)122-127
Number of pages6
JournalSouth African Journal of Botany
Volume98
DOIs
StatePublished - May 1 2015

Keywords

  • Achillea fragrantissima
  • Analgesic
  • Anti-inflammatory
  • Anti-ulcerogenic
  • Egyptian folk medicine

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