Evaluation of a weighted multiple comparison procedure

Matthew C. Somerville; Timothy Wilson; Gary Koch; Peter Westfall

doi:10.1002/pst.136

Evaluation of a weighted multiple comparison procedure

Matthew C. Somerville, Timothy Wilson, Gary Koch, Peter Westfall

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6 Scopus citations

Abstract

We consider the problem of accounting for multiplicity for two correlated endpoints in the comparison of two treatments using weighted hypothesis tests. Various weighted testing procedures are reviewed, and a more powerful method (a variant of the weighted Simes test) is evaluated for the general bivariate normal case and for a particular clinical trial example. Results from these evaluations are summarized and indicate that the weighted methods perform in a manner similar to unweighted methods.

Original language	English
Pages (from-to)	7-13
Number of pages	7
Journal	Pharmaceutical Statistics
Volume	4
Issue number	1
DOIs	https://doi.org/10.1002/pst.136
State	Published - Jan 2005

Keywords

Hypothesis test
Multiplicity
Weighted multiple comparison

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10.1002/pst.136

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AB - We consider the problem of accounting for multiplicity for two correlated endpoints in the comparison of two treatments using weighted hypothesis tests. Various weighted testing procedures are reviewed, and a more powerful method (a variant of the weighted Simes test) is evaluated for the general bivariate normal case and for a particular clinical trial example. Results from these evaluations are summarized and indicate that the weighted methods perform in a manner similar to unweighted methods.

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Evaluation of a weighted multiple comparison procedure

Abstract

Keywords

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