Evaluation of a weighted multiple comparison procedure

Matthew C. Somerville, Timothy Wilson, Gary Koch, Peter Westfall

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


We consider the problem of accounting for multiplicity for two correlated endpoints in the comparison of two treatments using weighted hypothesis tests. Various weighted testing procedures are reviewed, and a more powerful method (a variant of the weighted Simes test) is evaluated for the general bivariate normal case and for a particular clinical trial example. Results from these evaluations are summarized and indicate that the weighted methods perform in a manner similar to unweighted methods.

Original languageEnglish
Pages (from-to)7-13
Number of pages7
JournalPharmaceutical Statistics
Issue number1
StatePublished - Jan 2005


  • Hypothesis test
  • Multiplicity
  • Weighted multiple comparison


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