Euphosantianane A–D: Antiproliferative premyrsinane diterpenoids from the endemic Egyptian plant euphorbia sanctae-catharinae

Mohamed Elamir F. Hegazy, Ahmed R. Hamed, Mahmoud A.A. Ibrahim, Zienab Talat, Eman H. Reda, Nahla S. Abdel-Azim, Faiza M. Hammouda, Seikou Nakamura, Hisashi Matsuda, Eman G. Haggag, Paul W. Paré, Thomas Efferth

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Euphorbia species are rich in diterpenes. A solvent extraction of Euphorbia sanctae-catharinae, a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (1–4) as well as previously reported metabolites (5–13) that included three flavonoids. Isolated compounds were chemically characterized by spectroscopic analysis. Identified compounds were bioassayed for anti-proliferative activity in vitro against colon (Caco-2) and lung (A549) tumor cell lines. Compound 9 exhibited robust anti-proliferative activity against A549 cells (IC50 = 3.3 µM). Absolute configurations for 8 versus 9 were determined by experimental and TDDFT-calculated electronic circular dichorism (ECD) spectra.

Original languageEnglish
Article number2221
JournalMolecules
Volume23
Issue number9
DOIs
StatePublished - Sep 1 2018

Keywords

  • Diterpenes
  • Euphorbia sanctae-catharinae
  • Euphorbiaceae
  • Flavonoids
  • TDDTF-ECD
  • Tumor anti-proliferative activity

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