TY - JOUR
T1 - Epileptic seizure detection and prediction based on continuous cerebral blood flow monitoring - A review
AU - Tewolde, Senay
AU - Oommen, Kalarickal
AU - Lie, Donald Y.C.
AU - Zhang, Yuanlin
AU - Chyu, Ming Chien
PY - 2015/6
Y1 - 2015/6
N2 - Epilepsy is the third most common neurological illness, affecting 1% of the world's population. Despite advances in medicine, about 25 to 30% of the patients do not respond to or cannot tolerate the severe side effects of medical treatment, and surgery is not an option for the majority of patients with epilepsy. The objective of this article is to review the current state of research on seizure detection based on cerebral blood flow (CBF) data acquired by thermal diffusion flowmetry (TDF), and CBF-based seizure prediction. A discussion is provided on the applications, advantages, and disadvantages of TDF in detecting and localizing seizure foci, as well as its role in seizure prediction. Also presented are an overview of the present challenges and possible future research directions (along with methodological guidelines) of the CBF-based seizure detection and prediction methods.
AB - Epilepsy is the third most common neurological illness, affecting 1% of the world's population. Despite advances in medicine, about 25 to 30% of the patients do not respond to or cannot tolerate the severe side effects of medical treatment, and surgery is not an option for the majority of patients with epilepsy. The objective of this article is to review the current state of research on seizure detection based on cerebral blood flow (CBF) data acquired by thermal diffusion flowmetry (TDF), and CBF-based seizure prediction. A discussion is provided on the applications, advantages, and disadvantages of TDF in detecting and localizing seizure foci, as well as its role in seizure prediction. Also presented are an overview of the present challenges and possible future research directions (along with methodological guidelines) of the CBF-based seizure detection and prediction methods.
KW - Cerebral perfusion
KW - Epilepsy
KW - Flowmetry
KW - Localization of seizure focus
UR - http://www.scopus.com/inward/record.url?scp=84943555845&partnerID=8YFLogxK
U2 - 10.1260/2040-2295.6.2.159
DO - 10.1260/2040-2295.6.2.159
M3 - Article
C2 - 26288885
AN - SCOPUS:84943555845
SN - 2040-2295
VL - 6
SP - 159
EP - 178
JO - Journal of Healthcare Engineering
JF - Journal of Healthcare Engineering
IS - 2
ER -