Energy Restricted Diet Benefits Body Composition but Degrades Bone Integrity in Middle-Aged Obese Female Rats

Chwan-Li Shen, Wenbin Zhu, Weimin Gao, Shu Wang, Lixia Chen, Ming-Chien Chyu

Research output: Contribution to journalArticlepeer-review

Abstract

This study investigates the effects of a restricted diet (RD) on body composition and musculoskeletal health along with endocrines and molecular mechanism in established mature obese rats. Twenty female rats were fed with a high-fat diet (HFD) ad libitum for 4 months and then assigned to either HFD or RD group for another 4 months. Another 10 rats were on a low-fat diet for 8 months. Outcome measures included body composition, bone mineral density, microarchitecrure, and strength; serum leptin, adiponectin, insulin-like growth factor I, and liver glutathione peroxidase activity; and protein expression and spleen tumor necrosis factor α messenger RNA expression. We hypothesized that mature obese rats on a 35% energy restriction diet for 4 months would improve body composition but degrade microstructural and mechanical properties of long bones, and such changes in musculoskeletal integrity are related to the modulation of obesity-related endocrines and proinflammation. Relative to HFD,
Original languageEnglish
Pages (from-to)668–676
JournalNutrition Research
StatePublished - Aug 2013

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