Energy intake, nonexercise physical activity, and weight loss in responders and nonresponders: The Midwest Exercise Trial 2

Stephen D. Herrmann, Erik A. Willis, Jeffery J. Honas, Jaehoon Lee, Richard A. Washburn, Joseph E. Donnelly

Research output: Contribution to journalArticle

17 Scopus citations


Objective To compare energy intake, total daily energy expenditure (TDEE), nonexercise energy expenditure (NEEx), resting metabolic rate (RMR), nonexercise physical activity (NEPA), and sedentary time between participants with weight loss <5% (nonresponders) vs. ≥5% (responders) in response to exercise. Methods Adults (18-30 years) with overweight/obesity (BMI 25-40 kg/m2) were randomized to exercise: 5 days/week, 400 or 600 kcal/session, 10 months. Results Of the participants, 40 responded and 34 did not respond to the exercise protocol. Nonresponder energy intake was higher vs. responders, significant only in men (P=0.034). TDEE increased only in responders (P=0.001). NEEx increased in responders and decreased in nonresponders, significant only in men (P=0.045). There were no within- or between-group differences for change in RMR. NEPA increased in responders and decreased in nonresponders (group-by-time interactions: total sample, P=0.049; men, P=0.016). Sedentary time decreased in both groups, significant only in men. Conclusions Men who did not lose weight in response to exercise (<5%) had higher energy intake and lower NEEx when compared with men losing ≥5%. No significant differences in any parameters assessed were observed between women who lost <5% vs. those losing ≥5%. Factors associated with the weight loss response to exercise in women warrant additional investigation.

Original languageEnglish
Pages (from-to)1539-1549
Number of pages11
Issue number8
StatePublished - Aug 1 2015


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