Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy

Murillo L. Martins, Andrea Orecchini, Luis Aguilera, Juergen Eckert, Jan Embs, Aleksander Matic, Margarida J. Saeki, Heloisa N. Bordallo

Research output: Contribution to journalConference articlepeer-review

4 Scopus citations

Abstract

The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.

Original languageEnglish
Article number02011
JournalEPJ Web of Conferences
Volume83
DOIs
StatePublished - Jan 23 2015
Event11th International Conference on Quasielastic Neutron Scattering, QENS 2014 and 6th International Workshop on Inelastic Neutron Spectrometers, WINS 2014 - Autrans, France
Duration: May 11 2014May 16 2014

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