Enantio- And Regioselective CuH-Catalyzed Conjugate Reduction of Yne-Allenones

Jia Yin Wang, Guigen Li, Wen Juan Hao, Bo Jiang

Research output: Contribution to journalArticlepeer-review

Abstract

A new asymmetric catalytic conjugate reduction of yne-allenones to synthesize enantioenriched cyclobuta[a]naphthalen-4(2H)-ones has been established that uses copper-bisphosphine complexes as catalysts and gives excellent regio- and enantioselectivities (≥99% ee) in most cases. This protocol tolerates a broad scope of substrates, exhibits high compatibility with various substituents, and gives excellent stereoselectivity, providing a catalytic and efficient entry to fabrication of synthetically important chiral 6-6-4 tricarbocyclic scaffolds.

Original languageEnglish
Pages (from-to)3828-3833
Number of pages6
JournalOrganic Letters
Volume23
Issue number10
DOIs
StatePublished - May 21 2021

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