Abstract
Fibrous microstructure has drawn extensive attention in tissue engineering due to its common presence in connective and muscle tissues. This paper reviews the latest advances in electrospinning as a nanofiber fabrication technique for biomimetic scaffolds. Specifically, we focus on scaffolds with gradients in element and structure, 3 D nanofiber scaffolds, and hydrogel scaffolds incorporated with nanofibers. Future directions of electrospinning research for tissue engineering are to realize the full potential of integrating the tunable 3 D fibrous microarchitecture in scaffold manufacturing at a clinically relevant scale, and to develop novel micro- and nano-scaffold architecture with modulated functionality for optimal tissue regeneration.
| Original language | English |
|---|---|
| Pages (from-to) | 947-960 |
| Number of pages | 14 |
| Journal | International Journal of Polymeric Materials and Polymeric Biomaterials |
| DOIs | |
| State | Published - 2019 |
Keywords
- Biomimetic scaffolds
- electrospinning
- nanofiber
- tissue engineering