Electrospinning of biomimetic fibrous scaffolds for tissue engineering: a review

George Z. Tan, Yingge Zhou

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


Fibrous microstructure has drawn extensive attention in tissue engineering due to its common presence in connective and muscle tissues. This paper reviews the latest advances in electrospinning as a nanofiber fabrication technique for biomimetic scaffolds. Specifically, we focus on scaffolds with gradients in element and structure, 3 D nanofiber scaffolds, and hydrogel scaffolds incorporated with nanofibers. Future directions of electrospinning research for tissue engineering are to realize the full potential of integrating the tunable 3 D fibrous microarchitecture in scaffold manufacturing at a clinically relevant scale, and to develop novel micro- and nano-scaffold architecture with modulated functionality for optimal tissue regeneration.

Original languageEnglish
Pages (from-to)947-960
Number of pages14
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
StatePublished - 2019


  • Biomimetic scaffolds
  • electrospinning
  • nanofiber
  • tissue engineering


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