Electroreductive 4-Pyridylation of Electron-deficient Alkenes with Assistance of Ni(acac)2

Sheng Zhang; Lijun Li; Xinru Li; Junqi Zhang; Kun Xu; Guigen Li; Michael Findlater

doi:10.1021/acs.orglett.0c01014

Electroreductive 4-Pyridylation of Electron-deficient Alkenes with Assistance of Ni(acac)₂

Sheng Zhang, Lijun Li, Xinru Li, Junqi Zhang, Kun Xu, Guigen Li, Michael Findlater

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

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Abstract

An electroreductive 4-pyridylation of activated alkenes was developed in an undivided cell with the assistance of Ni(acac)₂ (acac = acetylacetone). This novel protocol is compatible with a broad range of electron-poor alkenes, which are commonly regarded as challenging substrates in the previous conventional approaches. Moreover, a series of cyclic voltammetric experiments were conducted to reveal the unique role of Ni(acac)₂ differentiating reduction process of reaction partners.

Original language	English
Pages (from-to)	3570-3575
Number of pages	6
Journal	Organic Letters
Volume	22
Issue number	9
DOIs	https://doi.org/10.1021/acs.orglett.0c01014
State	Published - May 1 2020

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abstract = "An electroreductive 4-pyridylation of activated alkenes was developed in an undivided cell with the assistance of Ni(acac)2 (acac = acetylacetone). This novel protocol is compatible with a broad range of electron-poor alkenes, which are commonly regarded as challenging substrates in the previous conventional approaches. Moreover, a series of cyclic voltammetric experiments were conducted to reveal the unique role of Ni(acac)2 differentiating reduction process of reaction partners.",

author = "Sheng Zhang and Lijun Li and Xinru Li and Junqi Zhang and Kun Xu and Guigen Li and Michael Findlater",

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T1 - Electroreductive 4-Pyridylation of Electron-deficient Alkenes with Assistance of Ni(acac)2

AU - Zhang, Sheng

AU - Li, Lijun

AU - Li, Xinru

AU - Zhang, Junqi

AU - Xu, Kun

AU - Li, Guigen

AU - Findlater, Michael

PY - 2020/5/1

Y1 - 2020/5/1

N2 - An electroreductive 4-pyridylation of activated alkenes was developed in an undivided cell with the assistance of Ni(acac)2 (acac = acetylacetone). This novel protocol is compatible with a broad range of electron-poor alkenes, which are commonly regarded as challenging substrates in the previous conventional approaches. Moreover, a series of cyclic voltammetric experiments were conducted to reveal the unique role of Ni(acac)2 differentiating reduction process of reaction partners.

AB - An electroreductive 4-pyridylation of activated alkenes was developed in an undivided cell with the assistance of Ni(acac)2 (acac = acetylacetone). This novel protocol is compatible with a broad range of electron-poor alkenes, which are commonly regarded as challenging substrates in the previous conventional approaches. Moreover, a series of cyclic voltammetric experiments were conducted to reveal the unique role of Ni(acac)2 differentiating reduction process of reaction partners.

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JO - Organic Letters

JF - Organic Letters

IS - 9

ER -

Electroreductive 4-Pyridylation of Electron-deficient Alkenes with Assistance of Ni(acac)₂

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