TY - JOUR
T1 - Efficient photothermal therapy of brain cancer through porphyrin functionalized graphene oxide
AU - Su, Siheng
AU - Wang, Jilong
AU - Wei, Junhua
AU - Martínez-Zaguilán, Raul
AU - Qiu, Jingjing
AU - Wang, Shiren
N1 - Publisher Copyright:
© The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2015.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Current clinical treatments including surgical resection, radiation therapy and chemotherapy for brain cancer result in high mortality due to the complex structure of the brain aggressiveness of brain cancer. Recently, non-invasive photothermal therapy (PTT) using near infrared laser irradiation has been developed as an alternative emerging therapy for brain cancer. In this paper, a biocompatible porphyrin functionalized graphene oxide (PGO) with high absorbance at 808 nm is synthesized as a photothermal platform for brain cancer therapy. Graphite oxide is exfoliated and conjugated with porphyrin through π-π interactions. This PGO is two times more stable than reduced graphene oxide (rGO) in aqueous solution. Most importantly, the efficiency of the photo-thermal conversion of PGO is increased by 89% and 33% compared to graphene oxide and rGO under 808 nm laser irradiation, causing ablation of a large number of brain cancer cells in vitro. This PGO platform containing active functional groups allows specific targeting in PTT without harming healthy cells and tissues.
AB - Current clinical treatments including surgical resection, radiation therapy and chemotherapy for brain cancer result in high mortality due to the complex structure of the brain aggressiveness of brain cancer. Recently, non-invasive photothermal therapy (PTT) using near infrared laser irradiation has been developed as an alternative emerging therapy for brain cancer. In this paper, a biocompatible porphyrin functionalized graphene oxide (PGO) with high absorbance at 808 nm is synthesized as a photothermal platform for brain cancer therapy. Graphite oxide is exfoliated and conjugated with porphyrin through π-π interactions. This PGO is two times more stable than reduced graphene oxide (rGO) in aqueous solution. Most importantly, the efficiency of the photo-thermal conversion of PGO is increased by 89% and 33% compared to graphene oxide and rGO under 808 nm laser irradiation, causing ablation of a large number of brain cancer cells in vitro. This PGO platform containing active functional groups allows specific targeting in PTT without harming healthy cells and tissues.
UR - http://www.scopus.com/inward/record.url?scp=84933575376&partnerID=8YFLogxK
U2 - 10.1039/c5nj00122f
DO - 10.1039/c5nj00122f
M3 - Article
AN - SCOPUS:84933575376
SN - 1144-0546
VL - 39
SP - 5743
EP - 5749
JO - New Journal of Chemistry
JF - New Journal of Chemistry
IS - 7
ER -