TY - JOUR
T1 - Efficient nucleophilic substitution reactions of highly functionalized allyl halides in ionic liquid media
AU - Kotti, S. R.S.Saibabu
AU - Xu, Xin
AU - Li, Guigen
AU - Headley, Allan D.
N1 - Funding Information:
We gratefully acknowledge the National Institutes of Health (CA 99995-1) and the Robert A. Welch Foundation (D-1361, D-1460) for the generous support of this work, the National Science Foundation (CHE-9808436) for partial funding of the 500 MHz NMR spectrometer.
PY - 2004/2/9
Y1 - 2004/2/9
N2 - Nucleophilic substitution reactions of highly functionalized allyl halides with three anions, N3-, AcO-, and PhSO 2-, in ionic liquid media were conducted. The ionic liquid, [Bmim][BF4], was found to be superior to classical organic solvents to give higher yields and faster reaction rates. The resulting products belong to multifunctionalized trisubstituted α, β-unsaturated ketones, which are useful building blocks for organic synthesis.
AB - Nucleophilic substitution reactions of highly functionalized allyl halides with three anions, N3-, AcO-, and PhSO 2-, in ionic liquid media were conducted. The ionic liquid, [Bmim][BF4], was found to be superior to classical organic solvents to give higher yields and faster reaction rates. The resulting products belong to multifunctionalized trisubstituted α, β-unsaturated ketones, which are useful building blocks for organic synthesis.
KW - Halides
KW - Ionic liquid
KW - S2 reaction
KW - α,β-Unsaturated ketone
UR - http://www.scopus.com/inward/record.url?scp=1642497631&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2003.12.051
DO - 10.1016/j.tetlet.2003.12.051
M3 - Article
AN - SCOPUS:1642497631
SN - 0040-4039
VL - 45
SP - 1427
EP - 1431
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 7
ER -