TY - JOUR
T1 - Effects of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) metabolites on cricket (Acheta domesticus) survival and reproductive success
AU - Zhang, Baohong
AU - Freitag, Christina M.
AU - Cañas, Jaclyn E.
AU - Cheng, Qiuqiong
AU - Anderson, Todd A.
N1 - Funding Information:
This research was supported in part by the US Department of Defense contract CU1141, through the Strategic Environmental Research and Development Program (SERDP) under a Cooperative Agreement IERA-99-001 with the USAF, Institute of Environment, Safety, and Occupational Health, Brooks AFB, TX. C.M.F was supported in part by a Howard Hughes Medical Institute grant through the Undergraduate Biological Science Education Program to Texas Tech University.
PY - 2006/11
Y1 - 2006/11
N2 - The effect of two major hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) metabolites, hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX) and hexahydro-1,3,5-trinitroso-1,3,5-triazine (TNX), on cricket (Acheta domesticus) survival and reproduction was studied. RDX metabolites did not have adverse effects on cricket survival, growth, and egg production. However, MNX and TNX did affect egg hatching. MNX and TNX were more toxic in spiked-sand than in topical tests. TNX was more toxic to egg than MNX. Developmental stage and exposure time affected hatching. After 30 days exposure to MNX or TNX, the EC20, EC50, and EC95 were 47, 128, and 247 μg/g for TNX, and 65, 140, and 253 μg/g for MNX in topical tests. The ECs for 20, 50, and 95 were 21, 52, and 99 μg/g for MNX, and 12, 48, and 97 μg/g for TNX in sand. No gross abnormalities in cricket nypmhs were observed in all experiments indicating that neither TNX or MNX is teratogenic in this assay.
AB - The effect of two major hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) metabolites, hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX) and hexahydro-1,3,5-trinitroso-1,3,5-triazine (TNX), on cricket (Acheta domesticus) survival and reproduction was studied. RDX metabolites did not have adverse effects on cricket survival, growth, and egg production. However, MNX and TNX did affect egg hatching. MNX and TNX were more toxic in spiked-sand than in topical tests. TNX was more toxic to egg than MNX. Developmental stage and exposure time affected hatching. After 30 days exposure to MNX or TNX, the EC20, EC50, and EC95 were 47, 128, and 247 μg/g for TNX, and 65, 140, and 253 μg/g for MNX in topical tests. The ECs for 20, 50, and 95 were 21, 52, and 99 μg/g for MNX, and 12, 48, and 97 μg/g for TNX in sand. No gross abnormalities in cricket nypmhs were observed in all experiments indicating that neither TNX or MNX is teratogenic in this assay.
KW - Cricket
KW - Hexahydro-1,3,5-trinitro-1,3,5-triazine
KW - Reproductive toxicology, Acheta domesticus
UR - http://www.scopus.com/inward/record.url?scp=33748423955&partnerID=8YFLogxK
U2 - 10.1016/j.envpol.2006.01.023
DO - 10.1016/j.envpol.2006.01.023
M3 - Article
C2 - 16524652
AN - SCOPUS:33748423955
SN - 0269-7491
VL - 144
SP - 540
EP - 544
JO - Environmental Pollution
JF - Environmental Pollution
IS - 2
ER -