Effects of Curcumin in a Mouse Model of Very High Fat Diet-Induced Obesity

Iurii Koboziev, Shane Scoggin, Xiaoxia Gong, Parvin Mirzaei, Masoud Zabet Moghaddam, Mohammad Yosofvand, Hanna Moussa, Yava Jones-Hall, Naima Moustaid-Moussa

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract: Worldwide rates of Western-diet-induced obesity epidemics are growing dramatically. Beinglinkedwithnumerouscomorbiditiesandcomplications, includingcardiovasculardisease, type 2 diabetes, cancer, chronic inflammation, and osteoarthritis (OA), obesity represents one of the most threatening challenges for modern healthcare. Mouse models are an invaluable tool for investigating theeffectsofdietsandtheirbioactivecomponentsagainsthighfatdiet(HFD)-inducedobesityandits comorbidities. During recent years, very high fat diets (VHFDs), providing 58–60% kcal fat, have become a popular alternative to more traditional HFDs, providing 40–45% total kcal fat, due to the faster induction of obesity and stronger metabolic responses. This project aims to investigate if the 60% fat VHFD is suitable to evaluate the protective effects of curcumin in diet-induced obesity and osteoarthritis. B6 male mice, prone to diet-induced metabolic dysfunction, were supplemented with VHFD without or with curcumin
Original languageEnglish
JournalDefault journal
StatePublished - Sep 25 2020

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