Effects of Curcumin in a Mouse Model of Very High Fat Diet-Induced Obesity

Iurii Koboziev; Shane Scoggin; Xiaoxia Gong; Parvin Mirzaei; Masud Zabet Moghaddam; Mohammad Yosofvand; Hanna Moussa; Yava Jones-Hall; Naima Moustaid-Moussa

Effects of Curcumin in a Mouse Model of Very High Fat Diet-Induced Obesity

Iurii Koboziev, Shane Scoggin, Xiaoxia Gong, Parvin Mirzaei, Masud Zabet Moghaddam, Mohammad Yosofvand, Hanna Moussa, Yava Jones-Hall, Naima Moustaid-Moussa

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract: Worldwide rates of Western-diet-induced obesity epidemics are growing dramatically. Beinglinkedwithnumerouscomorbiditiesandcomplications, includingcardiovasculardisease, type 2 diabetes, cancer, chronic inﬂammation, and osteoarthritis (OA), obesity represents one of the most threatening challenges for modern healthcare. Mouse models are an invaluable tool for investigating theeﬀectsofdietsandtheirbioactivecomponentsagainsthighfatdiet(HFD)-inducedobesityandits comorbidities. During recent years, very high fat diets (VHFDs), providing 58–60% kcal fat, have become a popular alternative to more traditional HFDs, providing 40–45% total kcal fat, due to the faster induction of obesity and stronger metabolic responses. This project aims to investigate if the 60% fat VHFD is suitable to evaluate the protective eﬀects of curcumin in diet-induced obesity and osteoarthritis. B6 male mice, prone to diet-induced metabolic dysfunction, were supplemented with VHFD without or with curcumin

Original language	English
Journal	Default journal
State	Published - Sep 25 2020

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title = "Effects of Curcumin in a Mouse Model of Very High Fat Diet-Induced Obesity",

abstract = "Abstract: Worldwide rates of Western-diet-induced obesity epidemics are growing dramatically. Beinglinkedwithnumerouscomorbiditiesandcomplications, includingcardiovasculardisease, type 2 diabetes, cancer, chronic inﬂammation, and osteoarthritis (OA), obesity represents one of the most threatening challenges for modern healthcare. Mouse models are an invaluable tool for investigating theeﬀectsofdietsandtheirbioactivecomponentsagainsthighfatdiet(HFD)-inducedobesityandits comorbidities. During recent years, very high fat diets (VHFDs), providing 58–60% kcal fat, have become a popular alternative to more traditional HFDs, providing 40–45% total kcal fat, due to the faster induction of obesity and stronger metabolic responses. This project aims to investigate if the 60% fat VHFD is suitable to evaluate the protective eﬀects of curcumin in diet-induced obesity and osteoarthritis. B6 male mice, prone to diet-induced metabolic dysfunction, were supplemented with VHFD without or with curcumin",

author = "Iurii Koboziev and Shane Scoggin and Xiaoxia Gong and Parvin Mirzaei and Moghaddam, {Masud Zabet} and Mohammad Yosofvand and Hanna Moussa and Yava Jones-Hall and Naima Moustaid-Moussa",

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language = "English",

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publisher = "Current Opinion in Endocrinology Diabetes and Obesity",

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T1 - Effects of Curcumin in a Mouse Model of Very High Fat Diet-Induced Obesity

AU - Koboziev, Iurii

AU - Scoggin, Shane

AU - Gong, Xiaoxia

AU - Mirzaei, Parvin

AU - Moghaddam, Masud Zabet

AU - Yosofvand, Mohammad

AU - Moussa, Hanna

AU - Jones-Hall, Yava

AU - Moustaid-Moussa, Naima

PY - 2020/9/25

Y1 - 2020/9/25

N2 - Abstract: Worldwide rates of Western-diet-induced obesity epidemics are growing dramatically. Beinglinkedwithnumerouscomorbiditiesandcomplications, includingcardiovasculardisease, type 2 diabetes, cancer, chronic inﬂammation, and osteoarthritis (OA), obesity represents one of the most threatening challenges for modern healthcare. Mouse models are an invaluable tool for investigating theeﬀectsofdietsandtheirbioactivecomponentsagainsthighfatdiet(HFD)-inducedobesityandits comorbidities. During recent years, very high fat diets (VHFDs), providing 58–60% kcal fat, have become a popular alternative to more traditional HFDs, providing 40–45% total kcal fat, due to the faster induction of obesity and stronger metabolic responses. This project aims to investigate if the 60% fat VHFD is suitable to evaluate the protective eﬀects of curcumin in diet-induced obesity and osteoarthritis. B6 male mice, prone to diet-induced metabolic dysfunction, were supplemented with VHFD without or with curcumin

AB - Abstract: Worldwide rates of Western-diet-induced obesity epidemics are growing dramatically. Beinglinkedwithnumerouscomorbiditiesandcomplications, includingcardiovasculardisease, type 2 diabetes, cancer, chronic inﬂammation, and osteoarthritis (OA), obesity represents one of the most threatening challenges for modern healthcare. Mouse models are an invaluable tool for investigating theeﬀectsofdietsandtheirbioactivecomponentsagainsthighfatdiet(HFD)-inducedobesityandits comorbidities. During recent years, very high fat diets (VHFDs), providing 58–60% kcal fat, have become a popular alternative to more traditional HFDs, providing 40–45% total kcal fat, due to the faster induction of obesity and stronger metabolic responses. This project aims to investigate if the 60% fat VHFD is suitable to evaluate the protective eﬀects of curcumin in diet-induced obesity and osteoarthritis. B6 male mice, prone to diet-induced metabolic dysfunction, were supplemented with VHFD without or with curcumin

M3 - Article

JO - Default journal

JF - Default journal

ER -

Effects of Curcumin in a Mouse Model of Very High Fat Diet-Induced Obesity

Abstract

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