Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and β-oxidation of fatty acid in OLETF rats

Shaikh Mizanoor Rahman, Yu Ming Wang, Hiroaki Yotsumoto, Jae Young Cha, Seo Young Han, Shuji Inoue, Teruyoshi Yanagita

Research output: Contribution to journalArticle

145 Scopus citations

Abstract

We investigated the efficacy of a 4-wk supplementation of conjugated linoleic acid (CLA) as free fatty acid (FFA) or triacylglycerol (TG) on serum leptin concentration, body-fat accumulation, and mitochondrial β-oxidation in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. A significant reduction of serum leptin concentration (42%) and a decrease in the wet weights of perirenal, epididymal, and omental/visceral-adipose tissue in TG-CLA and FFA-CLA groups were found in comparison with the OLETF control group. Both forms of CLA supplementation produced a 5.2% decrease in body weight compared with the control even though food intake was similar in the OLETF groups. Moreover, both forms of CLA enhanced carnitine-palmitoyltransferase activity in brown adipose tissue, perirenal adipose tissue, red gastrocnemius muscle, and liver in comparison with the OLETF control group. Serum concentrations of non-esterified fatty acid and TG also were reduced in rats fed diets supplemented with TG-CLA and FFA-CLA.

Original languageEnglish
Pages (from-to)385-390
Number of pages6
JournalNutrition
Volume17
Issue number5
DOIs
StatePublished - May 2001

Keywords

  • Brown adipose tissue
  • Carnitine-palmitoyltransferase activity
  • Conjugated linoleic acid
  • Gastrocnemius muscle
  • Leptin
  • Perirenal adipose tissue
  • Serum lipids

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