TY - JOUR
T1 - Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and β-oxidation of fatty acid in OLETF rats
AU - Rahman, Shaikh Mizanoor
AU - Wang, Yu Ming
AU - Yotsumoto, Hiroaki
AU - Cha, Jae Young
AU - Han, Seo Young
AU - Inoue, Shuji
AU - Yanagita, Teruyoshi
PY - 2001/5
Y1 - 2001/5
N2 - We investigated the efficacy of a 4-wk supplementation of conjugated linoleic acid (CLA) as free fatty acid (FFA) or triacylglycerol (TG) on serum leptin concentration, body-fat accumulation, and mitochondrial β-oxidation in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. A significant reduction of serum leptin concentration (42%) and a decrease in the wet weights of perirenal, epididymal, and omental/visceral-adipose tissue in TG-CLA and FFA-CLA groups were found in comparison with the OLETF control group. Both forms of CLA supplementation produced a 5.2% decrease in body weight compared with the control even though food intake was similar in the OLETF groups. Moreover, both forms of CLA enhanced carnitine-palmitoyltransferase activity in brown adipose tissue, perirenal adipose tissue, red gastrocnemius muscle, and liver in comparison with the OLETF control group. Serum concentrations of non-esterified fatty acid and TG also were reduced in rats fed diets supplemented with TG-CLA and FFA-CLA.
AB - We investigated the efficacy of a 4-wk supplementation of conjugated linoleic acid (CLA) as free fatty acid (FFA) or triacylglycerol (TG) on serum leptin concentration, body-fat accumulation, and mitochondrial β-oxidation in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. A significant reduction of serum leptin concentration (42%) and a decrease in the wet weights of perirenal, epididymal, and omental/visceral-adipose tissue in TG-CLA and FFA-CLA groups were found in comparison with the OLETF control group. Both forms of CLA supplementation produced a 5.2% decrease in body weight compared with the control even though food intake was similar in the OLETF groups. Moreover, both forms of CLA enhanced carnitine-palmitoyltransferase activity in brown adipose tissue, perirenal adipose tissue, red gastrocnemius muscle, and liver in comparison with the OLETF control group. Serum concentrations of non-esterified fatty acid and TG also were reduced in rats fed diets supplemented with TG-CLA and FFA-CLA.
KW - Brown adipose tissue
KW - Carnitine-palmitoyltransferase activity
KW - Conjugated linoleic acid
KW - Gastrocnemius muscle
KW - Leptin
KW - Perirenal adipose tissue
KW - Serum lipids
UR - http://www.scopus.com/inward/record.url?scp=0034996014&partnerID=8YFLogxK
U2 - 10.1016/S0899-9007(00)00584-0
DO - 10.1016/S0899-9007(00)00584-0
M3 - Article
C2 - 11377131
AN - SCOPUS:0034996014
SN - 0899-9007
VL - 17
SP - 385
EP - 390
JO - Nutrition
JF - Nutrition
IS - 5
ER -